Description
The main objective pursued in the drafting of the PDTA of the Veneto Regional Oncological Network – ROV (DGR 2067/2013) is to ensure timeliness in taking care of patients, adequate levels of care and continuity of care from the precise moment in which the patient enters the path, to multidisciplinary evaluation, up to the end of life.
The definition of PDTAs also provides for the identification of structure, process and outcome indicators which will allow the acquisition of “effectiveness” data of diagnostic, therapeutic and organizational innovations.
Background
The IOV is a fundamental hub in the hospital and territorial Regional Oncological Network, as it acts as a HUB for its coordination in close harmony with all the organizations in the Region. Among its objectives is to define and share Diagnostic Therapeutic Assistance Pathways for the various types of cancer and to activate systems of verification and indicators for monitoring the appropriateness of care pathways and oncological treatment oriented to the quality and safety of the patient. Therefore, the collection of indicators within the Institute becomes of strategic importance, which also assumes essential importance at the regional level. The relevance of real world data is growing in light of the continuous diagnostic, therapeutic and organizational innovations in the oncology field.
Rationale
The monitoring of the PDTA through specific performance indicators makes it possible to analyze the assistance junctions put in place at the individual company declination. The verification in the field of the improvements introduced by the PDTAs is carried out through the calculation of indicators, ie variables with other information content, which allow a synthetic evaluation of complex phenomena and help to guide decisions. The indicators are currently constructed using the information made available by current information flows (specialist assistance, hospitalizations, pharmaceuticals, home care, regional mortality register) suitably integrated with record linkage techniques.
The ability to detect structure, process and outcome indicators will allow to produce reliable data from clinical practice. The relevance of “effectiveness” data deriving from clinical practice is now also recognized by the regulatory authorities as the only way to obtain:
- long-term safety data of innovative therapies,
- efficacy data in patients under / not represented in clinical trials (elderly, with comorbidities, compromised clinical conditions, taking various drugs),
- efficacy data in tumors / rare clinical pictures with insufficient data from clinical studies,
- data on therapeutic sequences.
Global Goals
Evaluation of the adherence to the indicators expressed by the PDTAs of the ROV, of the patients in charge of the IOV in the various treatment paths, specifically by:
- monitoring adherence to indicators;
- implementing internal audits;
- analyzing any corrective systems;
- acquiring outcome data.
Expected and measurable results over the three-year period
Activation of an application that allows the detection of structure and process indicators “detectable” by the regional information flows in order to allow the verification of the real taking in charge of the cancer patient as defined in the various PDTAs of the ROV. Measurable activities for the verification of the results through the quantitative definition of the indicator are:
- waiting time to start post-operative chemotherapy / radiotherapy
- chemotherapy in the last 30 days of life
- reduction of inappropriate diagnostic tests (CT, MRI, PET, etc)
- definition of evaluation tools on the effectiveness of innovative therapies.
| Titolo | Testata | IF grezzo | Autori |
|---|---|---|---|
| STYLE (NCT03449173): A Phase 2 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines | JOURNAL OF THORACIC ONCOLOGY | 20,40 | Claudia Proto, Sara Manglaviti, Giuseppe Lo Russo, Marco Musca, Giulia Galli, Martina Imbimbo, Matteo Perrino, Nadia Cordua, Eliana Rulli, Zelmira Ballatore, Dal Maso Alessandro, Antonio Chella, Andrea Sbrana, Arsela Prelaj, Roberto Ferrara, Mario Occhipinti, Marta Brambilla, Alessandro De Toma, Laura Mazzeo, Teresa Beninato, Diego Signorelli, Giacomo Massa, Francesca Gabriella Greco, Giuseppina Calareso, Daniela Miliziano, Rosa Maria Di Mauro, Giulia Mella, Alessandra Lucarelli, Paggio Angela, Francesca Galli, Valter Torri, Filippo Guglielmo Maria De Braud, Pasello Giulia, Iacopo Petrini, Rossana Berardi, Monica Ganzinelli, Marina Chiara Garassino, Paolo Andrea Zucali |
| Secondary prevention and treatment innovation of early stage non-small cell lung cancer: Impact on diagnostic-therapeutic pathway from a multidisciplinary perspective | CANCER TREATMENT REVIEWS | 11,80 | Pasello Giulia, Daniela Scattolin, Bonanno Laura, Caumo Francesca, Andrea Dell’Amore, Scagliori Elena, Mariaenrica Tinè, Fiorella Calabrese, Gaetano Benati, Sepulcri Matteo, Cristina Baiocchi, Michele Milella, Federico Rea, Guarneri Valentina |
| European e-Delphi process to define expert consensus on electrochemotherapy treatment indications, procedural aspects, and quality indicators in melanoma | BRITISH JOURNAL OF SURGERY | 9,60 | Luca G Campana, Sofia Farronato, Jackie Hodgetts, Joy Odili, Vecchiato Antonella, Alison Bracken, Susanne Baier, Falk G Bechara, Lorenzo Borgognoni, Corrado Caracò, Sara Carvalhal, Piero Covarelli, James Clover, Klaus Eisendle, Fabrizio Fantini, Maria Teresa Fierro, Victor Farricha, Chiara Gregorelli, Jürg Hafner, Christian Kunte, Gianni Gerlini, Schapoor Hessam, Mario Mandalà, Dario Piazzalunga, Pietro Quaglino, Marko Snoj, Alastair Mackenzie Ross, Béatrice Trigona, David Moreno-Ramirez, Francesca Tauceri, Howard Peach, Piotr Rutkowski, Tobian Muir, Francesca De Terlizzi, Roberto Patuzzo, Michael Mühlstädt, Karin-Almut Dietrich, Thomas Mussack, Paolo Matteucci, Erika Kis, Paolo Ascierto, Gregor Sersa, Sara Valpione |
| Real-world EGFR testing practices for non-small-cell lung cancer by thoracic pathology laboratories across Europe | ESMO OPEN | 7,30 | P. Hofman, F. Calabrese, I. Kern, J. Adam, A. Alarcão, I. Alborelli, N.T. Anton, A. Arndt, A. Avdalyan, M. Barberis, H. Bégueret, B. Bisig, H. Blons, P. Boström, L. Brcic, G. Bubanovic, A. Buisson, A. Caliò, M. Cannone, L. Carvalho, C. Caumont, A. Cayre, L. Chalabreysse, M.P. Chenard, E. Conde, M.C. Copin, J.F. Côté, N. D’Haene, H.Y. Dai, L. De Leval, P. Delongova, M. Den?I?-Fekete, A. Fabre, F. Ferenc, F. Forest, F. De Fraipont, M. Garcia-Martos, G. Gauchotte, R. Geraghty, E. Guerin, D. Guerrero, S. Hernandez, P. Hurník, B. Jean-Jacques, K. Kashofer, D. Kazdal, S. Lantuejoul, C. Leonce, A. Lupo, U. Malapelle, R. Matej, J.L. Merlin, K.D. Mertz, A. Morel, A. Mutka, N. Normanno, P. Ovidiu, A. Panizo, M.G. Papotti, E. Parobkova, Pasello Giulia, P. Pauwels, G. Pelosi, F. Penault-Llorca, T. Picot, N. Piton, A. Pittaro, G. Planchard, N. Poté, T. Radonic, I. Rapa, A. Rappa, C. Roma, M. Rot, J.C. Sabourin, I. Salmon, S. Savic Prince, A. Scarpa, E. Schuuring, I. Serre, V. Siozopoulou, D. Sizaret, S. Smojver-Ježek, J. Solassol, K. Steinestel, J. Stojši?, C. Syrykh, S. Timofeev, G. Troncone, A. Uguen, S. Valmary-Degano, A. Vigier, M. Volante, S.G.F. Wahl, A. Stenzinger, M. Ilié |
| Vascular/epithelial changes as late sequelae after recovery from SARS-COV-2 infection: an in-vivo comparative study | HISTOPATHOLOGY | 6,40 | Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Gheorghe E Olteanu, Francesco Fortarezza, Alessandro De Pellegrin, Luca Melan, Eleonora Faccioli, Elisa De Franceschi, Chiara Giraudo, Claudia Del Vecchio, Serena Marinello, Pasello Giulia, Dario Gregori, Paolo Navalesi, Federico Rea, Marco Schiavon, Fiorella Calabrese |
| Standardized and simplified reporting of next-generation sequencing results in advanced non-small-cell lung cancer: Practical indications from an Italian multidisciplinary group | CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 6,20 | Umberto Malapelle, Alessandro Delle Donne, Fabio Pagni, Filippo Fraggetta, Elena Guerini Rocco, Pasello Giulia, Giuseppe Perrone, Francesco Pepe, Simona Vatrano, Sandro Pignata, Carmine Pinto, Giancarlo Pruneri, Antonio Russo, Hector J. Soto Parra, Stefania Vallone, Antonio Marchetti, Giancarlo Troncone, Silvia Novello |
| Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 5,60 | Giulia Pretelli, Calogera Claudia Spagnolo, Giuliana Ciappina, Mariacarmela Santarpia, Pasello Giulia |
| Targeting MET in Non-Small Cell Lung Cancer (NSCLC): A New Old Story? | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 5,60 | Calogera Claudia Spagnolo, Giuliana Ciappina, Elisa Giovannetti, Andrea Squeri, Barbara Granata, Chiara Lazzari, Giulia Pretelli, Pasello Giulia, Mariacarmela Santarpia |
| 10 Years of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A Systematic Review and Meta-Analysis | CANCERS | 5,20 | Andrea Di Giorgio, Antonio Macrì, Federica Ferracci, Manuela Robella, Mario Visaloco, Giovanni De Manzoni, Paolo Sammartino, Sommariva Antonio, Daniele Biacchi, Franco Roviello, Roberta Pastorino, Denise Pires Marafon, Stefano Rotolo, Francesco Casella, Marco Vaira |
| Diagnostic and Therapeutic Algorithm for Appendiceal Tumors and Pseudomyxoma Peritonei: A Consensus of the Peritoneal Malignancies Oncoteam of the Italian Society of Surgical Oncology (SICO) | CANCERS | 5,20 | Marco Vaira, Manuela Robella, Marcello Guaglio, Paola Berchialla, Sommariva Antonio, Mario Valle, Enrico Maria Pasqual, Franco Roviello, Massimo Framarini, Giammaria Fiorentini, Paolo Sammartino, Alba Ilari Civit, Andrea Di Giorgio, Luca Ansaloni, Marcello Deraco |
| Enhanced Recovery after Surgery (ERAS) Program for Patients with Peritoneal Surface Malignancies Undergoing Cytoreductive Surgery with or without HIPEC: A Systematic Review and a Meta-Analysis | CANCERS | 5,20 | Manuela Robella, Tonello Marco, Paola Berchialla, Veronica Sciannameo, Alba Maria Ilari Civit, Sommariva Antonio, Cinzia Sassaroli, Andrea Di Giorgio, Roberta Gelmini, Valentina Ghirardi, Franco Roviello, Fabio Carboni, Piero Vincenzo Lippolis, Shigeki Kusamura, Marco Vaira |
| Gastric Cancer (GC) with Peritoneal Metastases (PMs): An Overview of Italian PSM Oncoteam Evidence and Study Purposes | CANCERS | 5,20 | Paolo Sammartino, Giovanni De Manzoni, Luigi Marano, Daniele Marrelli, Daniele Biacchi, Sommariva Antonio, Stefano Scaringi, Orietta Federici, Marcello Guaglio, Marco Angrisani, Maurizio Cardi, Alessia Fassari, Francesco Casella, Luigina Graziosi, Franco Roviello |
| Microscopical Variables and Tumor Inflammatory Microenvironment Do Not Modify Survival or Recurrence in Stage I-IIA Lung Adenocarcinomas | CANCERS | 5,20 | Andrea Dell¿Amore, Alessandro Bonis, Luca Melan, Stefano Silvestrin, Giorgio Cannone, Fares Shamshoum, Alberto Zampieri, Federica Pezzuto, Fiorella Calabrese, Samuele Nicotra, Marco Schiavon, Eleonora Faccioli, Marco Mammana, Giovanni Maria Comacchio, Pasello Giulia, Federico Rea |
| Precision Surgery in NSCLC | CANCERS | 5,20 | Giorgio Cannone, Giovanni Maria Comacchio, Pasello Giulia, Eleonora Faccioli, Marco Schiavon, Andrea Dell¿Amore, Marco Mammana, Federico Rea |
| Repeated Cytoreduction Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Selected Patients Affected by Peritoneal Metastases: Italian PSM Oncoteam Evidence | CANCERS | 5,20 | Enrico Maria Pasqual, Ambrogio P. Londero, Manuela Robella, Tonello Marco, Sommariva Antonio, Michele De Simone, Stefano Bacchetti, Gianluca Baiocchi, Salvatore Asero, Federico Coccolini, Franco De Cian, Marcello Guaglio, Armando Cinquegrana, Cenzi Carola, Stefano Scaringi, Antonio Macrì |
| The Pattern of Progression to First-Line Treatment with Dabrafenib and Trametinib in Patients with Unresectable or Metastatic, BRAF-Mutated, Cutaneous Melanoma: Results of the Observational T-WIN Study | CANCERS | 5,20 | Michele Del Vecchio, Chiarion Sileni Vanna, Pietro Quaglino, Gaetana Rinaldi, Alessandro Minisini, Teresa Troiani, Francesca Consoli, Andrea Sponghini, Maria Banzi, Maria Francesca Morelli, Dario Palleschi, Ernesto Rossi, Riccardo Marconcini, Roberta Depenni, Fabrizio Carnevale-Schianca, Ilaria Marcon, Paola Queirolo |
| Titolo | Testata | IF grezzo | Autori |
|---|---|---|---|
| Pericardial Mesothelioma, a Disease for Brave Hearts | Journal of Thoracic Oncology | 20,12 | Federica Grosso, Luigi Cerbone, Pasello Giulia |
| A Definitive Prognostication System for Patients With Thoracic Malignancies Diagnosed With Coronavirus Disease 2019: An Update From the TERAVOLT Registry | Journal of Thoracic Oncology | 20,12 | Jennifer G. Whisenant, Javier Baena, Alessio Cortellini, Li-Ching Huang, Giuseppe Lo Russo, Luca Porcu, Selina K. Wong, Christine M. Bestvina, Matthew D. Hellmann, Elisa Roca, Hira Rizvi, Isabelle Monnet, Amel Boudjemaa, Jacobo Rogado, Pasello Giulia, Natasha B. Leighl, Oscar Arrieta, Avinash Aujayeb, Ullas Batra, Ahmed Y. Azzam, Mojca Unk, Mohammed A. Azab, Ardak N. Zhumagaliyeva, Carlos Gomez-Martin, Juan B. Blaquier, Erica Geraedts, Giannis Mountzios, Gloria Serrano-Montero, Niels Reinmuth, Linda Coate, Melina Marmarelis, Carolyn J. Presley, Fred R. Hirsch, Pilar Garrido, Hina Khan, Alice Baggi, Celine Mascaux, Balazs Halmos, Giovanni L. Ceresoli, Mary J. Fidler, Vieri Scotti, Anne-Cécile Métivier, Lionel Falchero, Enriqueta Felip, Carlo Genova, Julien Mazieres, Umit Tapan, Julie Brahmer, Emilio Bria, Sonam Puri, Sanjay Popat, Karen L. Reckamp, Floriana Morgillo, Ernest Nadal, Francesca Mazzoni, Francesco Agustoni, Jair Bar, Federica Grosso, Virginie Avrillon, Jyoti D. Patel, Fabio Gomes, Ehab Ibrahim, Annalisa Trama, Anna C. Bettini, Fabrice Barlesi, Anne-Marie Dingemans, Heather Wakelee, Solange Peters, Leora Horn, Marina Chiara Garassino, Valter Torri |
| Bridging therapeutic opportunities: a survey by the Italian molecular tumor board workgroup of Alliance Against Cancer | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 12,66 | Gennaro Ciliberto, Marco Canfora, Irene Terrenato, Agnoletto Chiara, Francesco Agustoni, Loredana Amoroso, Gustavo Baldassarre, Giuseppe Curigliano, Angelo Delmonte, Antonella De Luca, Michelangelo Fiorentino, Vanesa Gregorc, Toni Ibrahim, Chiara Lazzari, Angela Mastronuzzi, Paolo Pronzato, Armando Santoro, Giovanni Scambia, Stefania Tommasi, Andrea Vingiani, Patrizio Giacomini, Ruggero De Maria |
| The oncological multidimensional prognostic index is a promising decision-making tool: A real-world analysis in older patients with metastatic colorectal cancer | EUROPEAN JOURNAL OF CANCER | 10,00 | PROCACCIO LETIZIA, bergamo francesca, Maura Gatti, Chiusole Benedetta, Tierno Giuseppina, Bergo Eleonora, Daniel Francesca, Floriana Nappo, Giulia Maddalena, Cosimo Rasola, Giulia Barsotti, Maria C. De Grandis, Vittoria M. Piva, Rizzato Mario Domenico, Giuseppe Sergi, Brunello Antonella, zagonel vittorina, Lonardi Sara |
| Final results of DIADEM, a phase II study to investigate the efficacy and safety of durvalumab in advanced pretreated malignant pleural mesothelioma | ESMO Open | 6,88 | S. Canova, G.L. Ceresoli, F. Grosso, P.A. Zucali, F. Gelsomino, Pasello Giulia, M. Mencoboni, E. Rulli, F. Galli, I. De Simone, L. Carlucci, A. De Angelis, M. Belletti, M. Bonomi, A. D’Aveni, M. Perrino, F. Bono, D.L. Cortinovis |
| Position paper of the Italian Association of Medical Oncology on the impact of COVID-19 on Italian oncology and the path forward: the 2021 Matera statement | ESMO Open | 6,88 | G.D. Beretta, R. Casolino, D.C. Corsi, F. Perrone, M. Di Maio, S. Cinieri, G. Gobber, M. Bellani, F. Petrini, M.T. Zocchi, F. Traclò, zagonel vittorina |
| Evaluation of COVID-19 impact on DELAYing diagnostic-therapeutic pathways of lung cancer patients in Italy (COVID-DELAY study): fewer cases and higher stages from a real-world scenario | ESMO Open | 6,88 | L. Cantini, G. Mentrasti, G.L. Russo, D. Signorelli, Pasello Giulia, E. Rijavec, M. Russano, L. Antonuzzo, D. Rocco, R. Giusti, V. Adamo, C. Genova, A. Tuzi, A. Morabito, S. Gori, N.L. Verde, R. Chiari, A. Cortellini, V. Cognigni, F. Pecci, A. Indini, A. De Toma, E. Zattarin, S. Oresti, E.G. Pizzutilo, Frega Stefano, E. Erbetta, A. Galletti, F. Citarella, S. Fancelli, E. Caliman, L. Della Gravara, U. Malapelle, M. Filetti, M. Piras, G. Toscano, L. Zullo, M. De Tursi, P. Di Marino, V. D’Emilio, M.S. Cona, A. Guida, A. Caglio, F. Salerno, G. Spinelli, C. Bennati, F. Morgillo, A. Russo, C. Dellepiane, I. Vallini, V. Sforza, A. Inno, F. Rastelli, V. Tassi, L. Nicolardi, V. Pensieri, R. Emili, E. Roca, A. Migliore, T. Galassi, M. L. Bruno Rocchi, R. Berardi |
| Alternative academic approaches for testing homologous recombination deficiency in ovarian cancer in the MITO16A/MaNGO-OV2 trial | ESMO Open | 6,88 | E.D. Capoluongo, B. Pellegrino, L. Arenare, D. Califano, G. Scambia, L. Beltrame, V. Serra, G.L. Scaglione, A. Spina, S.C. Cecere, R. De Cecio, N. Normanno, N. Colombo, D. Lorusso, D. Russo, C. Nardelli, M. D’Incalci, A. Llop-Guevara, C. Pisano, G. Baldassarre, D. Mezzanzanica, G. Artioli, M. Setaro, Tasca Giulia, C. Roma, N. Campanini, S. Cinieri, A. Sergi, A. Musolino, F. Perrone, P. Chiodini, S. Marchini, S. Pignata |
| Laparoscopic Cytoreduction Combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Peritoneal Surface Malignancies (PSM): Italian PSM Oncoteam Evidence and Literature Review | Cancers | 6,58 | Sommariva Antonio, Mario Valle, Roberta Gelmini, Tonello Marco, Fabio Carboni, Giovanni De Manzoni, Lorena Sorrentino, Enrico Maria Pasqual, Stefano Bacchetti, Cinzia Sassaroli, Andrea Di Giorgio, Massimo Framarini, Daniele Marrelli, Francesco Casella, Orietta Federici |
| Colorectal Cancer with Peritoneal Metastases: The Impact of the Results of PROPHYLOCHIP, COLOPEC, and PRODIGE 7 Trials on Peritoneal Disease Management | Cancers | 6,58 | Sommariva Antonio, Tonello Marco, Federico Coccolini, Giovanni De Manzoni, Paolo Delrio, PIZZOLATO ELISA, Roberta Gelmini, Francesco Serra, Erion Rreka, Enrico Maria Pasqual, Luigi Marano, Daniele Biacchi, Fabio Carboni, Shigeki Kusamura, Paolo Sammartino |
| Advanced Adrenocortical Carcinoma: From Symptoms Control to Palliative Care | Cancers | 6,58 | Elena Ruggiero, Irene Tizianel, Caccese Mario, LOMBARDI GIUSEPPE, Pambuku Ardi, zagonel vittorina, Carla Scaroni, Formaglio Fabio, Filippo Ceccato |
| Simultaneous Care in Oncology: A 7-Year Experience at ESMO Designated Centre at Veneto Institute of Oncology, Italy | Cancers | 6,58 | Brunello Antonella, Galiano Antonella, Schiavon Stefania, Nardi Mariateresa, FELTRIN ALESSANDRA, Pambuku Ardi, DE TONI CHIARA, Dal Col Alice, LAMBERTI EVELINA, Chiara Pittarello, bergamo francesca, BASSO UMBERTO, MARUZZO MARCO, Finotto Silvia, Bolshinsky Maital, Stragliotto Silvia, PROCACCIO LETIZIA, Rizzato Mario Domenico, Formaglio Fabio, LOMBARDI GIUSEPPE, Lonardi Sara, zagonel vittorina |
| Direct Costs of Care for Adults with Soft Tissue Sarcomas: A Population-Based Study | Cancers | 6,58 | Massimo Rugge, Alessandra Buja, TROPEA SAVERIA, Giovanni Girardi, Luigi Cosenza Franzese, COZZOLINO CLAUDIA, Manuel Zorzi, VECCHIATO ANTONELLA, DEL FIORE SANTO PAOLO, Brunello Antonella, Alessandra Rosalba Brazzale, Vincenzo Baldo, Angelo Paolo Dei Tos, Carlo Riccardo Rossi, MOCELLIN SIMONE |
| The Overall Survival and Progression-Free Survival in Patients with Advanced Adrenocortical Cancer Is Increased after the Multidisciplinary Team Evaluation | Cancers | 6,58 | Irene Tizianel, Caccese Mario, Francesca Torresan, LOMBARDI GIUSEPPE, Laura Evangelista, Filippo Crimì, Sepulcri Matteo, Maurizio Iacobone, Marta Padovan, Francesca Galuppini, zagonel vittorina, Carla Scaroni, Filippo Ceccato |
| Radiation Dose of Contrast-Enhanced Mammography: A Two-Center Prospective Comparison | Cancers | 6,58 | Gennaro Gisella Maria, Andrea Cozzi, Simone Schiaffino, Francesco Sardanelli, Caumo Francesca |