Chirurgia oncologica dell’esofago e delle vie digestive

Contatti

Mission

L’unità di Chirurgia oncologica dell’esofago e delle vie digestive svolge attività di diagnosi, cura e ricerca sulle neoplasie dell’apparato digerente, in particolare su quelle di esofago, stomaco e vie digestive. È centro di riferimento nazionale per il cancro del tratto esofageo, in collaborazione con il Dipartimento di Chirurgia dell’Azienda Ospedaliera – Università di Padova, ed è riconosciuta dalla Regione Veneto come unico centro regionale specializzato per la chirurgia oncologica dell’esofago.

La gestione del percorso terapeutico-chirurgico è di tipo multidisciplinare. Ogni paziente è preso in carico da un team di chirurghi, oncologi, radioterapisti, endoscopisti, anatomo-patologi e nutrizionisti che lo seguono in ogni fase. Il paziente può, inoltre, contare su personale dedicato all’organizzazione e prenotazione di esami e ricoveri. Grazie a questo modello organizzativo la preparazione all’intervento avviene prevalentemente in regime ambulatoriale, per ridurre al minimo la degenza preoperatoria, e dopo l’intervento viene data alla terapia del dolore e agli aspetti nutrizionali tutta l’attenzione necessaria.

A fianco delle degenze ordinarie è attivata la day surgery oncologica, che soddisfa le necessità cliniche connesse al posizionamento dei sistemi di accesso vascolare per chemioterapia, nonché alle procedure di radiologia interventistica.

L’unità di Chirurgia dell’esofago e delle vie digestive dispone di tutte le tecnologie più avanzate e si dedica allo sviluppo di tecniche chirurgiche mini-invasive con le quali effettua la maggior parte degli interventi.

La ricerca clinica e di base fa parte integrante dell’attività di diagnosi e cura per le neoplasie esofago-gastriche e del colon. I principali filoni di ricerca sono: carcinogenesi colica ed esofagea, obesità e carcinoma del cardias, chirurgia mini-invasiva toraco e laparoscopica, qualità di vita nei pazienti trattati con chemio-radioterapia e operati di esofagectomia e colectomia, uso dei biomarcatori in chirurgia oncologica dell’apparato digerente.

Avviso - Sospensione attività

Si avvisa la gentile utenza che l’attività dell’unità di Chirurgia oncologica dell’esofago e delle vie digestive è sospesa dal 01/07/2017 al 31/12/2017.

Ai pazienti già trattati viene garantita la continuità assistenziale attraverso la seguente attività ambulatoriale:

Le attività di chirurgia dell’intestino e del colon-retto passano in gestione all’unità di Chirurgia oncologica.

Attività Scientifica

An integral part of the activity of the Unit of Surgical Oncology is research. The Unit collaborates with research groups from other departments of the IOV and the University of Padua. Research activity focuses on clinical management, quality of life, immunology and cancerogenesis of digestive tract diseases.

The particular setting of an IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico; Institute of Scientific Research and Health Care) not only requires an innovative scientific approach to health care, it is able to provide a high standard of care to all patients. In this environment, the Unit of Surgical Oncology works in direct contact with the Padova City Hospital and the University of Padova, sharing clinical and research protocols, and in direct collaboration with all health care personnel.

This section outlines the different ongoing research projects on surgical oncology and is intended for researchers interested in the work currently being carried out in the Unit of Surgical Oncology. The last section is a collection of case reports on noteworthy disease presentation or surgical technique.

All collaborations are more than welcome!! For information, please contact the research group by email.

Clinical management of esophageal cancer

The research on clinical management of esophageal cancer is currently focused on:

  • Quality of life after esophageal resection for cancer
  • Clinical impact of minimally invasive esophagectomy
  • Management of patients who obtain complete response to neoadjuvant radiochemotherapy for esophageal cancer
  • Volume analysis of esophageal tumor before and after neoadjuvant therapy
  • Nodal metastasis distribution before and after neoadjuvant therapy for esophageal cancer

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. E. Ancona)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Ruol A, Rizzetto C, Castoro C, Cagol M, Alfieri R, Zanchettin G, Cavallin F, Michieletto S, Da Dalt G, Sileni VC, Corti L, Mantoan S, Zaninotto G, Ancona E. Interval between neoadjuvant chemoradiotherapy and surgery for squamous cell carcinoma of the thoracic esophagus: does delayed surgery have an impact on outcome? Ann Surg. 2010 Nov;252(5):788-96. PubMed PMID: 21037434.

Ruol A, Rampado S, Parenti A, Portale G, Giacomelli L, Battaglia G, Cagol M, Ancona E. Caustic ingestion and oesophageal cancer: intra- and peri-tumoral fibrosis is associated with a better prognosis. Eur J Cardiothorac Surg. 2010 Dec;38(6):659-64. Epub 2010 May 7. PubMed PMID: 20452236.

Cagol M, Ruol A, Castoro C, Alfieri R, Michieletto S, Ancona E. Prophylactic thoracic duct mass ligation prevents chylothorax after transthoracic esophagectomy for cancer. World J Surg. 2009 Aug;33(8):1684-6. PubMed PMID: 19533219.

Ruol A, Castoro C, Portale G, Cavallin F, Sileni VC, Cagol M, Alfieri R, Corti L, Boso C, Zaninotto G, Peracchia A, Ancona E. Trends in management and prognosis for esophageal cancer surgery: twenty-five years of experience at a single institution. Arch Surg. 2009 Mar;144(3):247-54; discussion 254. PubMed PMID: 19289664.

Ancona E, Rampado S, Cassaro M, Battaglia G, Ruol A, Castoro C, Portale G, Cavallin F, Rugge M. Prediction of lymph node status in superficial esophageal carcinoma. Ann Surg Oncol. 2008 Nov;15(11):3278-88. Epub 2008 Aug 26. PubMed PMID: 18726651.

Marano S, Ruol A, Castoro C, Portale G, Cagol M, Alfieri R, Michieletto S, Ancona E. Adenocarcinoma of the proximal esophagus: report of 9 patients and review of the literature. Ann Surg Oncol. 2008 Oct;15(10):2910-4. Epub 2008 Aug 12. PubMed PMID: 18696159.

Ruol A, Portale G, Castoro C, Merigliano S, Cagol M, Cavallin F, Chiarion Sileni V, Corti L, Rampado S, Costantini M, Ancona E. Effects of neoadjuvant therapy on perioperative morbidity in elderly patients undergoing esophagectomy for esophageal cancer. Ann Surg Oncol. 2007 Nov;14(11):3243-50. Epub 2007 Aug 23. PubMed PMID: 17713823.

Ruol A, Portale G, Castoro C, Merigliano S, Cavallin F, Battaglia G, Michieletto S, Ancona E. Management of esophageal cancer in patients aged over 80 years. Eur J Cardiothorac Surg. 2007 Sep;32(3):445-8. Epub 2007 Jul 23. PubMed PMID: 17643999.

Ruol A, Portale G, Zaninotto G, Cagol M, Cavallin F, Castoro C, Sileni VC, Alfieri R, Rampado S, Ancona E. Results of esophagectomy for esophageal cancer in elderly patients: age has little influence on outcome and survival. J Thorac Cardiovasc Surg. 2007 May;133(5):1186-92. PubMed PMID: 17467427.

Ancona E, Cagol M, Epifani M, Cavallin F, Zaninotto G, Castoro C, Alfieri R, Ruol A. Surgical complications do not affect longterm survival after esophagectomy for carcinoma of the thoracic esophagus and cardia. J Am Coll Surg. 2006 Nov;203(5):661-9. Epub 2006 Sep 27. PubMed PMID: 17084327.

Ruol A, Zaninotto G, Costantini M, Battaglia G, Cagol M, Alfieri R, Epifani M, Ancona E. Barrett’s esophagus: management of high-grade dysplasia and cancer. J Surg Res. 2004 Mar;117(1):44-51. Review. PubMed PMID: 15013713.

Petrin G, Ruol A, Battaglia G, Buin F, Merigliano S, Constantini M, Pavei P, Cagol M, Scappin S, Ancona E. Anastomotic stenoses occurring after circular stapling in esophageal cancer surgery. Surg Endosc. 2000 Jul;14(7):670-4. PubMed PMID: 10948307.

Merigliano S, Molena D, Ruol A, Zaninotto G, Cagol M, Scappin S, Ancona E. Chylothorax complicating esophagectomy for cancer: a plea for early thoracic duct ligation. J Thorac Cardiovasc Surg. 2000 Mar;119(3):453-7. PubMed PMID: 10694603.

Ancona E, Ruol A, Castoro C, Chiarion-Sileni V, Merigliano S, Santi S, Bonavina L, Peracchia A. First-line chemotherapy improves the resection rate and long-term survival of locally advanced (T4, any N, M0) squamous cell carcinoma of the thoracic esophagus: final report on 163 consecutive patients with 5-year follow-up. Ann Surg. 1997 Dec;226(6):714-23; discussion 723-4. PubMed PMID: 9409570; PubMed Central PMCID: PMC1191144.

Bardini R, Bonavina L, Asolati M, Ruol A, Castoro C, Tiso E. Single-layered cervical esophageal anastomoses: a prospective study of two suturing techniques. Ann Thorac Surg. 1994 Oct;58(4):1087-9; discussion 1089-90. PubMed PMID: 7944756.

Esophageal carcinogenesis

The research on esophageal carcinogenesis is currently focused on:

  • Animal models of the esophagitis, Barret esophagus, dysplasia and adenocarcinoma cascade
  • Role of costimulatory molecules in the immunosurveillance in esophagitis, Barrett’s esophagus, dysplasia and adenocarcinoma cascade
  • Role of VEGF determination in the prognosis of esophageal cancer


Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. E. Ancona)
  • Dept. of Diagnostic Sciences and Special Therapies (Pathology Unit), University of Padova (Prof. M. Rugge)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Fassan M, Cagol M, Pennelli G, Rizzetto C, Giacomelli L, Battaglia G, Zaninotto G, Ancona E, Ruol A, Rugge M. Programmed cell death 4 protein in esophageal cancer. Oncol Rep. 2010 Jul;24(1):135-9. PubMed PMID: 20514454.

Pasello G, Agata S, Bonaldi L, Corradin A, Montagna M, Zamarchi R, Parenti A, Cagol M, Zaninotto G, Ruol A, Ancona E, Amadori A, Saggioro D. DNA copy number alterations correlate with survival of esophageal adenocarcinoma patients. Mod Pathol. 2009 Jan;22(1):58-65. Epub 2008 Sep 26. PubMed PMID: 18820669.

Ingravallo G, Dall’Olmo L, Segat D, Fassan M, Mescoli C, Dazzo E, Castoro C, Polimeno L, Rizzetto C, Baroni MD, Zaninotto G, Ancona E, Rugge M. CDX2 hox gene product in a rat model of esophageal cancer. J Exp Clin Cancer Res. 2009 Aug 7;28:108. PubMed PMID: 19664209.

Ruol A, Parenti A, Zaninotto G, Merigliano S, Costantini M, Cagol M, AlfieriR, Bonavina L, Peracchia A, Ancona E. Intestinal metaplasia is the probable common precursor of adenocarcinoma in barrett esophagus and adenocarcinoma of the gastric cardia. Cancer. 2000 Jun 1;88(11):2520-8. PubMed PMID: 10861428

Upper GI endoscopy

The research on upper GI endoscopy is currently focused on:

  • Quality of life after palliative treatment of esophageal cancer

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. E. Ancona)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Diamantis G, Scarpa M, Bocus P, Realdon S, Castoro C, Ancona E, Battaglia G. Quality of life in patients with esophageal stenting for the palliation of malignant dysphagia. World J Gastroenterol. 2011 Jan 14;17(2):144-50. PubMed PMID: 21245986; PubMed Central PMCID: PMC3020367

Polese L, Angriman I, Scarpa M, Pagano D, Parente P, Erroi F, Frego M, D’Amico DF, Norberto L. Diode laser treatment of Barrett’s esophagus: long-term results. Lasers Med Sci. 2010 Sep 7. [Epub ahead of print] PubMed PMID: 20821340.

Polese L, Angriman I, Bonello E, Erroi F, Scarpa M, Frego M, D’Amico DF, Norberto L. Endoscopic dilation of benign esophageal strictures in a surgical unit: a report on 95 cases. Surg Laparosc Endosc Percutan Tech. 2007 Dec;17(6):477-81. PubMed PMID: 18097303.

Polese L, D’Incà R, Angriman I, Scarpa M, Pagano D, Ruffolo C, Lamboglia F, Sturniolo GC, D’Amico DF, Norberto L. Gastrointestinal telangiectasia: a study by EGD, colonoscopy, and capsule endoscopy in 75 patients. Endoscopy. 2008 Jan;40(1):23-9. Epub 2007 Dec 5. PubMed PMID: 18058652

Clinical management of lower GI cancers

The research on clinical management of lower GI cancer is currently focused on:

  • Quality of life after colonic resection for cancer
  • Clinical impact of minimally invasive colonic resection
  • Management of patients who obtain complete response to neoadjuvant radio chemotherapy for rectal cancer
  • Nodal metastasis distribution before and after neoadjuvant therapy for rectal cancer

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Dr. I. Angriman)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Scarpa M, Prando D, Pozza A, Esposti ED, Castoro C, Angriman I. A systematic review of diagnostic procedures to detect midgut neuroendocrine tumors. J Surg Oncol. 2010 Dec 1;102(7):877-88. Review. PubMed PMID: 20812262.

Ruffolo C, Scarpa M, Polese L, D’Amico FE, Boetto R, Pozza A, D’Incà R, Checchin D, Sturniolo GC, Bassi N, Angriman I. Clinical presentation and diagnosis of intestinal adenocarcinoma in Crohn’s disease: analysis of clinical predictors and of the life-time risk. J Gastrointest Surg. 2010 Nov;14(11):1746-51. Epub 2010 Jul 14. PubMed PMID: 20628906.

Scarpa M, Bertin M, Ruffolo C, Polese L, D’Amico DF, Angriman I. A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J Surg Oncol. 2008 Oct 1;98(5):384-92. Review. PubMed PMID: 18668671

Scarpa M, Erroi F, Ruffolo C, Angriman I. Decision making for metastatic diseases to the ovaries from colorectal cancer. J Surg Oncol. 2007 Dec 1;96(7):641-2. PubMed PMID: 17999403.

Erroi F, Scarpa M, Angriman I, Cecchetto A, Pasetto L, Mollica E, Bettiol M, Ruffolo C, Polese L, Cillo U, D’Amico DF. Ovarian metastasis from colorectal cancer: prognostic value of radical oophorectomy. J Surg Oncol. 2007 Aug 1;96(2):113-7. PubMed PMID: 17443728.

Bertin M, Angriman I, Scarpa M, Mencarelli R, Ranzato R, Ruffolo C, Polese L, Iacobone M, D’Amico DF. Prognosis of gastrointestinal stromal tumors. Hepatogastroenterology. 2007 Jan-Feb;54(73):124-8. PubMed PMID: 17419245.

Colonic cancinogenesis

The research on colonic carcinogenesis is currently focused on:

  • Animal model of the colitis, dysplasia and adenocarcinoma cascade
  • Role of costimulatory molecules in the immunosurveillance in ulcerative colitis, dysplasia and colonic adenocarcinoma cascade
  • Role of TLRs determination in the prognosis of colonic cancer

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. G.C. Sturniolo, Dr. I. Angriman, Dr. M. Bortolami)
  • Dept. of Histology, Microbiology and Medical Biotechnologies, University of Padova (Prof. I. Castagliuolo)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Scarpa M, Bortolami M, Cecchetto A, Faggian D, Kotsafti A, Ruffolo C, Navaglia F, Pozza A, D’Incà R, Plebani M, Sturniolo GC, Angriman I. Mucosal immune environment in colonic carcinogenesis: CD80 up-regulation in colonic dysplasia in ulcerative colitis. Eur J Cancer. 2010 Nov 8. [Epub ahead of print] PubMed PMID: 21067914.

Scarpa M, van Koperen PJ, Ubbink DT, Hommes DW, Ten Kate FJ, Bemelman WA. Systematic review of dysplasia after restorative proctocolectomy for ulcerative colitis. Br J Surg. 2007 May;94(5):534-45. Review. PubMed PMID: 17443850

Scarpa M, Behboo R, Angriman I, Cecchetto A, D’Incà R, Termini B, Barollo M, Ruffolo C, Polese L, Sturniolo GC, D’Amico DF. Expression of costimulatory molecule CD80 in colonic dysplasia in ulcerative colitis: an immunosurveillance mechanism against colorectal cancer? Int J Colorectal Dis. 2006 Dec;21(8):776-83. Epub 2006 Mar 7. PubMed PMID: 16520930.

Barollo M, D’Inca R, Scarpa M, Medici V, Cardin R, Bortolami M, Ruffolo C, Angriman I, Sturniolo GC. Effects of iron manipulation on trace elements level in a model of colitis in rats. World J Gastroenterol. 2005 Jul 28;11(28):4396-9. PubMed PMID: 16038040.

Barollo M, D’Incà R, Scarpa M, Medici V, Cardin R, Fries W, Angriman I, Sturniolo GC. Effects of iron deprivation or chelation on DNA damage in experimental colitis. Int J Colorectal Dis. 2004 Sep;19(5):461-6. Epub 2004 Apr 6. PubMed PMID: 15067556.

Scarpa M, Behboo R, Angriman I, Termini B, Barollo M, Ruffolo C, Polese L, D’Incà R, Sturniolo GC, D’Amico DF. The role of costimulatory molecules CD80 and CD86 and IFNgamma in the pathogenesis of ulcerative colitis. Dig Dis Sci. 2004 Nov-Dec;49(11-12):1738-44. PubMed PMID: 15628695.

Immunology in inflammatory bowel disease

The research on immunology of inflammatory bowel disease is currently focused on:

  • Immune response to microbiota in pouchitis
  • Immune response to microbiota in ulcerative colitis
  • Cytokine network in perianal Crohn’s disease

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. G.C. Sturniolo, Dr. I. Angriman, Dr. M. Bortolami)
  • Dept. of Histology, Microbiology and Medical Biotechnologies, University of Padova (Prof. I. Castagliuolo)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Ruffolo C, Scarpa M, Bassi N. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N Engl J Med. 2010 Sep 9;363(11):1086-7; author reply 1087-8. PubMed PMID: 20848681

D’Incà R, Barollo M, Scarpa M, Grillo AR, Brun P, Vettorato MG, Castagliuolo I, Sturniolo GC. Rectal Administration of Lactobacillus casei DG Modifies Flora Composition and Toll-Like Receptor Expression in Colonic Mucosa of Patients with Mild Ulcerative Colitis. Dig Dis Sci. 2010 Aug 25. [Epub ahead of print] PubMed PMID: 20737210

Ruffolo C, Scarpa M, Faggian D, Basso D, D’Incà R, Plebani M, Sturniolo GC, Bassi N, Angriman I. Subclinical intestinal inflammation in patients with Crohn’s disease following bowel resection: a smoldering fire. J Gastrointest Surg. 2010 Jan;14(1):24-31. Epub 2009 Nov 10. PubMed PMID: 19902313.

Garolla A, D’Incà R, Checchin D, Biagioli A, De Toni L, Nicoletti V, Scarpa M, Bolzonello E, Sturniolo GC, Foresta C. Reduced endothelial progenitor cell number and function in inflammatory bowel disease: a possible link to the pathogenesis. Am J Gastroenterol. 2009 Oct;104(10):2500-7. Epub 2009 Jun 30. PubMed PMID: 19568231.

Scarpa M, Bortolami M, Morgan SL, Kotsafti A, Ferraro S, Ruffolo C, D’Incà R, Polese L, Barollo M, D’Amico DF, Sturniolo GC, Angriman I. TGF-beta1 and IGF-1 production and recurrence of Crohn’s disease after ileo-colonic resection. J Surg Res. 2009 Mar;152(1):26-34. Epub 2008 May 7. PubMed PMID: 19027918.

Scarpa M, Bortolami M, Morgan SL, Kotsafti A, Ruffolo C, D’Incà R, Bertin E, Polese L, D’Amico DF, Sturniolo GC, Angriman I. TGF-beta1 and IGF-1 and anastomotic recurrence of Crohn’s disease after ileo-colonic resection. J Gastrointest Surg. 2008 Nov;12(11):1981-90. Epub 2008 Aug 13. PubMed PMID: 18704594

Ruffolo C, Scarpa M, Faggian D, Pozza A, Navaglia F, D’Incà R, Hoxha P, Romanato G, Polese L, Sturniolo GC, Plebani M, D’Amico DF, Angriman I. Cytokine network in rectal mucosa in perianal Crohn’s disease: relations with inflammatory parameters and need for surgery. Inflamm Bowel Dis. 2008 Oct;14(10):1406-12. PubMed PMID: 18452203.

Ruffolo C, Scarpa M, Faggian D, Romanato G, De Pellegrin A, Filosa T, Prando D, Polese L, Scopelliti M, Pilon F, Ossi E, Frego M, D’Amico DF, Angriman I. Cytokine network in chronic perianal Crohn’s disease and indeterminate colitis after colectomy. J Gastrointest Surg. 2007 Jan;11(1):16-21. PubMed PMID: 17390181.

Polese L, De Franchis G, Scarpa M, Sturniolo GC, Ruffolo C, Norberto L, Frego M, D’Amico DF, Angriman I. B1a lymphocytes in ulcerative colitis. Int J Colorectal Dis. 2007 Sep;22(9):1005-11. Epub 2007 Mar 20. PubMed PMID: 17372743

Polese L, Angriman I, Giuseppe DF, Cecchetto A, Sturniolo GC, Renata D, Scarpa M, Ruffolo C, Norberto L, Frego M, D’Amico DF. Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis. World J Gastroenterol. 2005 Sep 14;11(34):5303-8. PubMed PMID: 16149136.

Quality of life after lower GI surgery

The research on quality of life after lower GI surgery is currently focused on:

  • Quality of life after colonic resection for cancer
  • Quality of life in diverticular disease

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. G.C. Sturniolo, Dr. I. Angriman)

Related publications

Scarpa M. Quality of life after surgery of the alimentary tract. World J Gastroenterol. 2010 Oct 28;16(40):5020-3. PubMed PMID: 20976837; PubMed Central PMCID: PMC2965277.

Angriman I, Scarpa M, Ruffolo C. Health related quality of life after surgery for colonic diverticular disease. World J Gastroenterol. 2010 Aug 28;16(32):4013-8. PubMed PMID: 20731014; PubMed Central PMCID: PMC2928454

Scarpa M, Ruffolo C, Bassi D, Boetto R, D’Incà R, Buda A, Sturniolo GC, Angriman I. Intestinal surgery for Crohn’s disease: predictors of recovery, quality of life, and costs. J Gastrointest Surg. 2009 Dec;13(12):2128-35. Epub 2009 Sep 25. PubMed PMID: 19779944.

Scarpa M, Mescoli C, Rugge M, D’Incà R, Ruffolo C, Polese L, D’Amico DF, Sturniolo GC, Angriman I. Restorative proctocolectomy for inflammatory bowel disease: the Padova prognostic score for colitis in predicting long-term outcome and quality of life. Int J Colorectal Dis. 2009 Sep;24(9):1049-57. Epub 2009 Apr 22. PubMed PMID: 19415309.

Scarpa M, Victor CJ, O’Connor BI, Cohen Z, McLeod RS. Validation of an English version of the Padova quality of life instrument to assess quality of life following ileal pouch anal anastomosis. J Gastrointest Surg. 2009 Mar;13(3):416-22. Epub 2008 Dec 17. PubMed PMID: 19089514.

Scarpa M, Pagano D, Ruffolo C, Pozza A, Polese L, Frego M, D’Amico DF, Angriman I. Health-related quality of life after colonic resection for diverticular disease: long-term results. J Gastrointest Surg. 2009 Jan;13(1):105-12. Epub 2008 Aug 27. PubMed PMID: 18751760.

Scarpa M, Erroi F, Ruffolo C, Mollica E, Polese L, Pozza G, Norberto L, D’Amico DF, Angriman I. Minimally invasive surgery for colorectal cancer: quality of life, body image, cosmesis, and functional results. Surg Endosc. 2009 Mar;23(3):577-82. Epub 2008 Apr 4. PubMed PMID: 18389312.

Scarpa M, Ruffolo C, Polese L, Martin A, D’Incà R, Sturniolo GC, D’Amico DF, Angriman I. Quality of life after restorative proctocolectomy for ulcerative colitis: different questionnaires lead to different interpretations. Arch Surg. 2007 Feb;142(2):158-65. PubMed PMID: 17309967.

Scarpa M, Ruffolo C, D’Incà R, Filosa T, Bertin E, Ferraro S, Polese L, Martin A, Sturniolo GC, Frego M, D’Amico DF, Angriman I. Health-related quality of life after ileocolonic resection for Crohn’s disease: long-term results. Inflamm Bowel Dis. 2007 Apr;13(4):462-9. PubMed PMID: 17206691.

Scarpa M, Angriman I, Ruffolo C, Ferronato A, Polese L, Barollo M, Martin A, Sturniolo GC, D’Amico DF. Health-related quality of life after ristorative proctocolectomy for ulcerative colitis: long-term results. World J Surg. 2004 Feb;28(2):124-9. Epub 2004 Jan 8. PubMed PMID: 14708057.

Ileostomy and colostomy

The research on ileostomy and colostomy is currently focused on:

  • Rehabilitation of pelvic floor after ileo-anal anastomosis.

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. G.C. Sturniolo, Dr. I. Angriman, Dr. M. Bortolami)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Scarpa M, Ruffolo C, Boetto R, Pozza A, Sadocchi L, Angriman I. Diverting loop ileostomy after restorative proctocolectomy: predictors of poor outcome and poor quality of life. Colorectal Dis. 2010 Sep;12(9):914-20. Epub 2009 Apr 13. PubMed PMID: 19508537.

Scarpa M, Sadocchi L, Ruffolo C, Iacobone M, Filosa T, Prando D, Polese L, Frego M, D’Amico DF, Angriman I. Rod in loop ileostomy: just an insignificant detail for ileostomy-related complications? Langenbecks Arch Surg. 2007 Mar;392(2):149-54. Epub 2006 Nov 28. PubMed PMID: 17131157

Scarpa M, Barollo M, Keighley MR. Ileostomy for constipation: long-term postoperative outcome. Colorectal Dis. 2005 May;7(3):224-7. PubMed PMID: 15859958.

Scarpa M, Barollo M, Polese L, Keighley MR. Quality of life in patients with an ileostomy. Minerva Chir. 2004 Feb;59(1):23-9. Review. PubMed PMID: 15111829.

Mylonakis E, Scarpa M, Barollo M, Yarnoz C, Keighley MR. Life table analysis of hernia following end colostomy construction. Colorectal Dis. 2001 Sep;3(5):334-7. PubMed PMID: 12790956.

Metabolic changes after intestinal surgery

The research on metabolic changes after intestinal surgery is currently focused on:

  • Role of adipose tissue on the esophageal carcinogenesis.

Collaborations

  • Clinica Medica III, University of Padova (Prof. R. Vettor)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Romanato G, Scarpa M, Angriman I, Faggian D, Ruffolo C, Marin R, Zambon S, Basato S, Zanoni S, Filosa T, Pilon F, Manzato E. Plasma lipids and inflammation in active inflammatory bowel diseases. Aliment Pharmacol Ther. 2009 Feb 1;29(3):298-307. Epub 2008 Nov 8. PubMed PMID: 19035968.

Romanato G, Scarpa M, Ruffolo C, Marin R, Zambon S, Zanoni S, Basato S, Filosa T, Pilon F, Angriman I, Manzato E. Lipid and phospholipid Profile after bowel resection for Crohn’s disease. Int J Colorectal Dis. 2008 Oct;23(10):931-8. Epub 2008 Jul 3. PubMed PMID: 18597099.

Scarpa M, Romanato G, Manzato E, Ruffolo C, Marin R, Basato S, Zambon S, Filosa T, Zanoni S, Pilon F, Polese L, Sturniolo GC, D’Amico DF, Angriman I. Restorative proctocolectomy for ulcerative colitis: impact on lipid metabolism and adipose tissue and serum fatty acids. J Gastrointest Surg. 2008 Feb;12(2):279-87. Epub 2007 Oct 23. PubMed PMID: 17955308.

Case reports

  • Peculiar cases or surgical techniques that occurred in our clinical practice are reported.

Collaborations

  • Dept. of Surgical and Gastroenterological Sciences, University of Padova (Prof. E. Ancona, Prof. G.C. Sturniolo, Dr. I. Angriman, Dr. M. Bortolami)
  • Endoscopy Unit, Veneto Institute of Oncology (Dr. G. Battaglia)

Related publications

Fassan M, Castoro C, Saenz AJ, Cagol M, Ninfo V, Rugge M. Inflammatory myofibroblastic tumor as adverse outcome of eosinophilic esophagitis. Endoscopy. 2009;41 Suppl 2:E95-6. Epub 2009 Apr 24. PubMed PMID: 19396747.

Blandamura S, Altavilla G, Castoro C, Antonini C, Piazza M. Combined granular cell tumour of the oesophagus and stomach: a case report and review of the literature. Ital J Gastroenterol. 1993 Jun;25(5):259-64. Review. PubMed PMID: 8353300.

Bonavina L, Pavanello M, Baisi A, Castoro C, Ancona E, Peracchia A. Mediastinal cyst involving the oesophagus: diagnosis and results of surgical treatment. Eur J Surg. 1996 Sep;162(9):703-7. PubMed PMID: 8908451.

Mescoli C, Castoro C, Sergio A, Ruol A, Farinati F, Rugge M. Hepatic spleen nodules (HSN). Scand J Gastroenterol. 2010 May;45(5):628-32. PubMed PMID: 20408775.

Bassi D, Ruffolo C, Scarpa M, Mescoli C, Bassi N, Angriman I. Ileal neuroendocrine carcinoma following restorative proctocolectomy for colonic adenocarcinoma in Crohn’s disease. Int J Colorectal Dis. 2011 Feb;26(2):253-4. Epub 2010 Jun 8. PubMed PMID: 20532536.

Ruffolo C, Scarpa M, Bassi D, Angriman I. Inflammatory fibroid polyp causing intestinal obstruction following restorative proctocolectomy for ulcerative colitis. Dig Surg. 2009;26(4):285-6. Epub 2009 Jul 8. PubMed PMID: 19590208.

Ruffolo C, Scarpa M, Polese L, Angriman I. Adenocarcinoma after ristorative proctocolectomy for cancer in ulcerative colitis. Int J Colorectal Dis. 2007 Dec;22(12):1557-8. Epub 2007 Feb 6. PubMed PMID: 17279349

Ruffolo C, Angriman I, Scarpa M, D’Odorico A, Polese L, Barollo M, Bertin M, Pagano D, D’Amico DF. A gastrocolic fistula in Crohn’s disease. Dig Dis Sci. 2005 May;50(5):933-4. PubMed PMID: 15906771.

Ruffolo C, Angriman I, Montesco MC, Scarpa M, Polese L, Barollo M, Pagano D, D’Amico DF. Unusual cause of small bowel perforation: metastasis of a subcutaneous angiosarcoma of the head. Int J Colorectal Dis. 2005 Nov;20(6):551-2. Epub 2005 Jan 14. PubMed PMID: 15650826

Ruffolo C, Angriman I, Scarpa M, Polese L, Barollo M, Bertin M, Pagano D, D’Amico DF. Minimally invasive management of Crohn’s disease complicated by ureteral stenosis. Surg Laparosc Endosc Percutan Tech. 2004 Oct;14(5):292-4. PubMed PMID: 15492662.

Dove siamo

Via Gattamelata, 64 - 35128 Padova